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have a digenetic life cycle, involving a motile, extracellular promastigote stage that parasitizes the alimentary tract of the sandfly vector and an immotile amastigote phase that survives and replicates from the phagolysosomes of mononuclear phagocytes [2,3]. Aside from humans, Main hosts of Leishmania, is unfold by the tsetse fly and brings about